If the ovum fails to become fertilized, the lining of the uterus sloughs off during menstruation. From puberty to menopause, this cycle of menstruation repeats monthly (except during pregnancy).

Approximately every 28 days during female ovulation an egg (ovum) is released from one of the ovaries and travels through the oviduct (fallopian tube) and into the uterus. At the same time, the endometrial lining of the uterus becomes prepared for implantation.

During intercourse, the penis ejaculates sperm, produced in the testes, into the vagina. Some of the sperm makes their way to the uterus where, if they encounter an egg to fertilize, unite with the ovum to form a fertilized egg or zygote. The zygote then may implant in the uterus and eventually develop into a fetus.