The biosphere is the global ecological system integrating all living beings and their relationships. This includes their interactions with the lithosphere (the rigid outer part of the earth, consisting of the crust and upper mantle), hydrosphere (all surface water), and atmosphere (the envelope of gases surrounding the planet).

Blood is categorized into four different types (A, B, AB, and O) based on the type of antigens found on the outside of the red blood cells. Additionally, each type can be negative or positive based on whether or not the cells have an antigen called the Rh factor.

After air enters through the nose, it passes through the nasal cavity which filters, moistens, and warms it. Further filtering takes place in the pharynx, which also helps protect against infection, and then in the trachea which is just past the epiglottis, responsible for preventing food from entering the airway.

The Kuiper Belt is similar to the asteroid belt but much larger. Extending beyond the orbit of Neptune, it contains objects composed mostly of frozen methane, ammonia, and water. Most notably, the Kuiper Belt is home to Pluto, a dwarf planet that, until a 2006 reclassification, was considered the ninth planet of the solar system.

In the mesosphere, temperature again drops as altitude increases until the coldest point in the Earth's atmosphere, the mesopause, is reached where temperatures fall to −225 °F (−143 °C).